Ah... One of my favorite expressions in Japanese. Unfortunately, like most fun to use expressions, it is a vulgar one ~_~. Fuzakenna yo is extremely vulgar. It basically means stop bullshitting me as the image suggests or the Japanese equivalent of go fuck yourself or GTFO. Therefore, as per usual, use with care :3

Interesting to note is what the actual verb 'fuzakeru' means. To make fun of, to flirt, to joke, to mess around are part of its definition.